An Improved One-pot Synthesis ofN α-(tert-Butoxycarbonyl)-O-(O′,O″-dialkylphosphoro)-L-tyrosines Using DialkylN,N-Diethylphosphoramidites
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (09) , 701-703
- https://doi.org/10.1055/s-1989-27366
Abstract
N α-(tert-Butoxycarbonyl)-O-(O′,O″-dialkylphosphoro)-L-tyrosines 6a-c were prepared in high yields by an efficient one-pot procedure, which involved initial tert-butyldimethylsilyl protection of the carboxy terminus of N-Boc tyrosine 1 followed by successive in situ phosphitylation of the tyrosyl hydroxyl group, oxidation of the resultant phosphite triester and deprotection.Keywords
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