The Failure of Sulphhydryl Compounds, AET, MEA, and Glutathione to Protect Against X-ray Induced Chromosome Aberrations in MaleDrosophila

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Abstract
Pre-treatment with the mammalian radioprotective sulphhydryl compounds AET (aminoethylisothiounum bromide), MEA (meicoptoethyl-amine) and glutathione did not protect the Drosophila testis from radiation-induced genetic damage. Protection was not given to spermatozoa, spermatids, spermatocytes and spermatogonia. The responses measured were production of recessive sex-linked lethals, translocations, deletions, loss of X and Y chromosomes and "dominant lethals". MEA increased the recessive lethals in the 3-6 day brood. Pre-treatment with glutathione increased the incidence of XO males in the 6-9 day brood and post-treat-ment in 0-3 day brood. MEA and glutathione increased the percentage of eggs that failed to develop in "dominant lethal" tests.