Visualization and quantification of transplanted dunning prostate tumors in rats using magnetic resonance imaging

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Abstract
Quantitative magnetic resonance imaging (MRI) has been used for the in vivo size determination of subcutaneously implanted Dunning R3327–H tumors in male Copenhagen‐Fisher rats (N = 18). Images have been recorded using a multislice spin‐echo sequence SE(1000/36) with a resolution of 0.2 times; 0.2 mm2 in the imaging plane and a slice thickness of 2 mm. The reliability in the MRI size determination was of the order of 10%. The MRI results were compared with caliper measurements. Five months after tumor implantation nine rats were castrated. Orchiectomy led to a marked and statistically significant reduction in tumor growth rate as determined by both methods of quantification. Qualitative MRI information regarding the tumor morphology was compared with that for histological specimens.