Deuteron and phosphorus-31 NMR study of the interaction of general anesthetics with phosphatidylcholine membranes

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Abstract
The effect of the general anesthetics .alpha.-chloralose and chloral hydrate as well as the nonanesthetic .beta.-chloralose on the order of phosphatidylcholine and phosphatidylcholine-cholesterol liposomes has been examined by 2H nuclear magnetic resonance. Chloral hydrate interacts with the hydrophilic head-group region, causing a change in the torsion angle of the C.alpha.-C.beta. bond. The membrane interior is also disordered by the presence of this agent. .alpha.-Chloralose, on the other hand, disorders only the central position of the membrane. .beta.-Chloralose produces little significant change in bilayer order.
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