The Effect of d-Tubocuraine on Respiratory Resistance in Anesthetized Man

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Abstract
Total respiratory resistance was measured during hyperventilation apnea in normal subjects anesthetized with nitrous oxide and halothane. Subsequent administration of d-tubocurarine caused no significant change in respiratory resistance. Bronchoconstriction and increased respiratory resistance are, therefore, not usual or expected responses to administration of d-tubocurarine. The mean value for respiratory resistance, 6.2 cm of water/liter/sec, is in good agreement with previously reported values in conscious, spontaneously breathing individuals.