Concise Synthesis of Deacetylanisomycin and 2-Substituted Analogues from N,2-O-Dibenzyl-L-threose Imine1

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Abstract
Anisomycin derivatives like deacetylanisomycin 8k and 2-substituted analogues have been prepared using a highly threo-selective addition of organolithium and Grignard compounds to N,2-O-dibenzyl-L-threose imine acetonide 4 and subsequent cyclization as key steps.