Hyperglycaemia and cardiovascular risk
- 1 December 2003
- journal article
- research article
- Published by Springer Nature in Acta Diabetologica
- Vol. 40 (S2) , s362-s369
- https://doi.org/10.1007/s00592-003-0121-z
Abstract
Cardiovascular diseases represent, today, the principal cause of mortality in the general population, especially in subjects with type 2 diabetes mellitus. In these patients the risk of death from cardiovascular diseases is equal to that of non-diabetic subjects with a previous episode of myocardial infarction. Many factors concur to determine such high risk. Hyperglycaemia contributes to the increase in morbidity and cardiovascular mortality associated with diabetes mellitus. Hyperglycaemia acts as a multipler of cardiovascular risk due to frequent association of multiple risk factors in diabetic patients. Therefore, effective treatment requires a more complete assessment of quantitative and qualitative aspects of glycemic control as well as all components of the diabetic syndrome or, more commonly, metabolic syndrome.Keywords
This publication has 15 references indexed in Scilit:
- Intensive Diabetes Therapy and Carotid Intima–Media Thickness in Type 1 Diabetes MellitusNew England Journal of Medicine, 2003
- In search of normoglycaemia in diabetes: controlling postprandial glucoseInternational Journal of Obesity, 2002
- Inhibition of Protein Kinase Cβ Prevents Impaired Endothelium-Dependent Vasodilation Caused by Hyperglycemia in HumansCirculation Research, 2002
- Biochemistry and molecular cell biology of diabetic complicationsNature, 2001
- Glycated proteins in diabetes2001
- Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitroDiabetologia, 2001
- Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk)BMJ, 2001
- Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients2000
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 1998
- The Bedford Survey: Ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabeticsDiabetologia, 1982