• 1 January 1979
    • journal article
    • research article
    • Vol. 6  (6) , 694-699
Abstract
Antibodies to ribonucleoprotein [RNP] are the serological marker of mixed connective tissue disease (MCTD). Five patients were presented who had negative or low titer anti-RNP antibodies despite characteristic MCTD. In all 5 patients antibodies to RNP appeared after they had taken prednisone for periods ranging from 3 wk to 15 mo.