A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog
- 1 January 1987
- journal article
- research article
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 10 (8) , 527-530
- https://doi.org/10.1185/03007998709108961
Abstract
SummaryA study was carried out using a model of myocardial ischaemia in the dog after ligation of the left coronary artery to determine the effects of the benzodiazepines, flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg of ischaemia. Their effects on haemodynamics were negligible. It is suggested that both benzodiazepines can be used for increasing electrical stability of the heart in patients with acute myocardial infarction and to inhibit the psychic stress response. Because of its short biological half-life and water solubility, allowing painless intravenous admini...Keywords
This publication has 1 reference indexed in Scilit:
- Stimulation threshold studies and the effect of antiarrhythmic drugsBasic Research in Cardiology, 1978