Effect of Various Hormones on Mammary Gland Growth of Ovariectomized Rats

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Abstract
The synergistic effect of various hormones upon mammary gland growth has been studied in adult ovariectomized rats stimulated with estradiol benzoate (EB) and progesterone (P) for 19 days. The mean DNA of 28 control rats was 5.57 mg/100 g bw. When treated with EB and P plus 3 units of insulin, a mean DNA of 6.89 mg/100 g bw, a significant increase of 24% (P< 0.05), was observed. EB and P plus growth hormone (GH) plus protamine zinc insulin increased the mean DNA to 7.62 mg/100 g bw, a highly significant increase of 37% (P< 0.001). When EB + P + GH + insulin + L-thyroxine (L-T4) were added, a mean DNA of 8.40 mg/100 g bw was observed, a highly significant increase of 51% (P< 0.001). Non-significant increases in DNA were observed with L-T4 and with L-T4 plus protamine zinc insulin.