A Formal Catalytic Asymmetric Synthesis of (+)-Biotin with Modified Cinchona Alkaloids
- 1 January 2001
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2001 (11) , 1737-1741
- https://doi.org/10.1055/s-2001-16748
Abstract
A formal catalytic asymmetric synthesis of (+)-biotin was realized. The key steps involve a catalytic, highly enantioselective and quantitative desymmetrization of a meso cyclic anhydride followed by a one-pot chemoselective reduction to form the optically active lactone intermediate in the Goldberg-Sternbach (+)-biotin synthesis.Keywords
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