TRIETHYLENE MELAMINE IN BRONCHOGENIC CARCINOMA WITH VENA CAVAL OBSTRUCTION
- 18 December 1954
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 156 (16) , 1493-1495
- https://doi.org/10.1001/jama.1954.02950160023007
Abstract
Considerable information concerning the usefulness, limitations, and toxicity of triethylene melamine (TEM) in neoplastic disease is now available.1The beneficial effects in the leukemias and lymphomas are well known.2Little benefit has been reported in neoplasms other than those of hematopoietic origin.3Nitrogen mustard (methyl β-chloroethyl amine) was employed by Raphael and Reilly in 56 cases of advanced bronchogenic carcinoma.4These authors reported alleviation of symptoms in 15 instances. Patients with superior vena caval obstruction and with tumors consisting of undifferentiated cells responded favorably. Triethylene melamine may be advantageously employed because of the greater ease of administration (oral) and the decreased incidence of constitutional symptoms, especially those referable to the gastrointestinal system.5Karnofsky and his co-workers originally reported four patients with inoperable bronchogenic carcinoma to be unimproved after triethylene melamine was employed.1aLenti and Gavosto6reported symptomatic improvement in 4 out of 10Keywords
This publication has 0 references indexed in Scilit: