Diuretic activity of Mannich base derivatives of ethacrynic acid and certain ethacrynic acid analogs
- 1 August 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (8) , 764-769
- https://doi.org/10.1021/jm00206a009
Abstract
Various Mannich base derivatives of selected phenoxyacetic acid type diuretics were synthesized, and their diuretic potency was evaluated in dogs. The Mannich bases possess little, if any, diuretic activity of their own. Those Mannich bases that do possess diuretic activity undoubtedly do so as a consequence of an elimination reaction (a retro-Michael type reaction) which yields the corresponding pharmacologically active .alpha.,.beta.-unsaturated ketone.This publication has 9 references indexed in Scilit:
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