Avoiding Psychic Adverse Effects during Induction of Neurolept Anaesthesia with Levomepromazine A Double‐Blind Study of Levomepromazine and Droperidol

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Abstract
Levomepromazine 0.1 μg/kg or droperidol 0.15 mg/kg for induction of neurolept anaesthesia were compared in a double‐blind prospective study of 60 patients undergoing upper abdominal surgery. On the morning after surgery, eight of 30 patients (26.7%) who received droperidol remembered having had unpleasant anxiety, or nightmarish or panicky experiences during induction of anaesthesia, whereas only one of 30 patients (3.3%) receiving levomepromazine experienced such unpleasant adverse effects (Ppp<0.0l). There was no difference between the two groups in the occurrence of postoperative nausea, restlessness, hallucinations, or sedation in the recovery ward. This study shows that levomepromazine is superior to droperidol for induction of neurolept anaesthesia because it gives less psychic adverse effects. more analgesia, and a deeper sedation, which is easily reversed with physostigmine at the end of anaesthesia.

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