Acute Effects of Parathyroid Hormone on Vitamin D Metabolism in Patients with the Bone Loss of Aging*

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Abstract
This study was carried out to evaluate the effects of an iv injection of parathyroid extract on serum levels of 1,25-dihydroxyvitamin D [1,25-(OH)2D3] in elderly osteopenic patients and age-matched nonosteopenic controls. Serum concentrations of 1,25-(OH)2D were reduced in elderly osteopenic subjects (mean ± SEM, 20 ± 3 pg/ml) compared with values in agematched nonosteopenic controls (35 ± 3 pg/ml), whereas no differences were found in serum 24,25-dihydroxyvitamin D levels (1.5 ± 0.3 and 2.2 ± 0.5 ng/ml, respectively). An iv injection of parathyroid extract was followed by a significant increase in serum 1,25-(OH)2D levels in both osteopenic patients (16 ± 6 pg/ml) and controls (15 ± 5 pg/ml). The mean 4-h increases in serum 1,25-(OH2D of 11–18 pg/ml were not significantly different in the two groups. The results indicate that the reduced 1,25-(OH)2D concentrations in the osteopenic patients are secondary to changes in factors that normally stimulate this enzyme system. (J Clin Endocrinol Metab54: 1258, 1982)

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