Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines
Top Cited Papers
- 23 January 2015
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 347 (6220) , 400-406
- https://doi.org/10.1126/science.1260668
Abstract
For T cells, variety is the spice of life: CD4 + helper T cells come in a variety of flavors. This allows them to respond in a manner that is tailored to the pathogen they encounter. Becattini et al. wondered whether multiple “flavors” of human CD4 + T cells respond to specific stimuli or if just one flavor dominates. To find out, they stimulated human memory CD4 + T cells with a fungus, a bacteria, or a vaccine antigen. Multiple helper cell subsets participated in each response. T cell receptor sequencing revealed that in some cases, T cells with the same specificity acquired different helper cell fates. Thus, there is more heterogeneity in human T cell responses than previously appreciated. Science , this issue p. 400Keywords
Funding Information
- European Research Council (323183 PREDICT)
- European Commission (FP7-HEALTH-2011-280873, FP7-HEALTH-2013-601958)
- Swiss National Science Foundation (149475, 147662)
- Helmut Horten Foundation.
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