The relationship of exposure to amphetamines and malignant lymphoma was evaluated using data collected by the Boston Collaborative Drug Surveillance Program. Of the 315 patients with this diagnosis, none gave a history of exposure to amphetamines, while among 38,900 control subjects 218 (0.56%) gave such a history. These findings do not lend support to the recently published hypothesis of an association between amphetamine usage and Hodgkin disease. (JAMA229:1462-1463, 1974)