Triggering p53 after cytokinesis failure
Open Access
- 7 June 2004
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 165 (5) , 607-608
- https://doi.org/10.1083/jcb.200405089
Abstract
Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed cytokinesis, making this phenomenon even more puzzling.Keywords
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