Salicylate Intoxication and Influenza in Ferrets
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Pediatric Research
- Vol. 13 (1) , 44-47
- https://doi.org/10.1203/00006450-197901000-00010
Abstract
Summary: A model of salicylate intoxication was developed in ferrets to permit the evaluation of the interaction with viruses isolated from patients with Reye's syndrome. Salicylate intoxication produced mild elevation of the serum glutamic oxaloacetic transaminase and fatty changes in the liver, but these changes differed from those seen in Reye's syndrome on light and electron microscopy. Salicylates were associated with decreased activity of hepatic phosphorylase and a slight depression of activity of ornithine transcarbamylase, a mitochondrial urea cycle enzyme. Infection with influenza viruses produced mild fatty changes in the liver, but did not significantly potentiate the effects of salicylate intoxication on the over-all mortality, the degree of fatty changes, or the hepatic enzymes. Influenza infection alone was not associated with decreased hepatic phosphorylase activity, but was associated with decreased activity of ornithine transcarbamylase. Influenza A was isolated from the livers of two of four animals cultured in embryonated eggs. Speculation: Because of its susceptibility to human influenza viruses, the ferret provides an animal model to evaluate potential toxic cofactors in the production of Reye's syndrome.Keywords
This publication has 5 references indexed in Scilit:
- Transiently Reduced Activity of Carbamyl Phosphate Synthetase and Ornithine Transcarbamylase in Liver of Children with Reye's SyndromeNew England Journal of Medicine, 1976
- BEHAVIOR IN FERRETS OF 2 CLOSELY RELATED CLONES OF INFLUENZA-VIRUS OF DIFFERING VIRULENCE FOR MAN1976
- Aspirin-Induced Hepatotoxicity in Patients with Systemic Lupus ErythematosusAnnals of Internal Medicine, 1974
- A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry, 1957
- SALICYLATE POISONINGAmerican Journal of Diseases of Children, 1945