Cyclic AMP in skin: effects of acute ischaemia
- 1 March 1975
- journal article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 92 (3) , 249-254
- https://doi.org/10.1111/j.1365-2133.1975.tb03073.x
Abstract
The cyclic adenosine 3′,5′-monophosphate (cyclic AMP) content of pig skin was measured several seconds to minutes after removal of the skin from the body. It increased very rapidly, reached a maximum by 2 min after removal (4 times higher than the initial level), then decreased very slowly. Propranolol injected into the animal before or added after the removal of the skin did not suppress this phenomenon. The practical significance of this finding (increase of cyclic AMP level in skin after ischaemia) is obvious—in order to measure cyclic AMP level in vivo, the sample must be frozen immediately to avoid an ‘artificial’ increase in cyclic AMP.Keywords
This publication has 9 references indexed in Scilit:
- The Cyclic Amp System in Normal and Psoriatic EpidermisJournal of Investigative Dermatology, 1972
- Adenyl Cyclase in Normal and Psoriatic SkinJournal of Investigative Dermatology, 1972
- Radioimmunoassay for Cyclic NucleotidesPublished by Elsevier ,1972
- Effects of phenothiazine tranquilizers on the cyclic 3′,5′-adenosine monophosphate system of rat brainNeuropharmacology, 1971
- Beta adrenergic stimulation of endogenous epidermal cyclic AMP formationArchives of Dermatology, 1971
- Phosphofructokinase (Pfk) Regulation of Glycolysis in SkinJournal of Investigative Dermatology, 1971
- MICROASSAY OF ADENOSINE‐3′,5′‐MONOPHOSPHATE (CYCLIC AMP) IN BRAIN AND OTHER TISSUES BY THE LUCIFERIN‐LUCIFERASE SYSTEM1Journal of Neurochemistry, 1971
- A Protein Binding Assay for Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1970
- Measurement of Adenosine 3’, 5’-Monophosphate (Cyclic AMP) in BrainPharmacology, 1970