A prepro-orexin gene polymorphism is associated with narcolepsy
- 9 January 2001
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 56 (1) , 115-117
- https://doi.org/10.1212/wnl.56.1.115
Abstract
The orexin (hypocretin) neurotransmitter system was recently shown to be directly involved in the pathogenesis of narcolepsy in two animal models. Furthermore, decreased levels of orexin A in the CSF were shown in narcoleptic patients. To define any genetic contribution of orexin to the etiology of narcolepsy, the authors screened the entire prepro-orexin gene for mutations or polymorphisms in 133 patients suffering from narcolepsy. They report an association of a rare polymorphism in the prepro-orexin gene with narcolepsy in a cohort of 178 patients.Keywords
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