Three glucose 6-phosphate dehydrogenase variants found in Japan
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 36 (3) , 327-334
- https://doi.org/10.1007/bf00446284
Abstract
Three Japanese glucose 6-phosphate dehydrogenase (G6PD) variants were investigated. G6PD ‘Mediterranean-like’ had markedly decreased activity, normal electrophoretic mobility, low Km G6P, low Km NADP, increased utilization of all three substrate analogues (2-deoxy-G6P, Gal-6P, and deamino-NADP) and slightly decreased heat stability and slightly biphasic pH curve. G6PD ‘Ogori’ had markedly decreased activity, but otherwise normal characteristics. G6PD ‘Hofu’ had moderately decreased activity, normal electrophoretic mobility, slightly reduced Km G6P, normal Km NADP, normal utilization of 2-deoxy-G6P and Gal-6P, but increased utilization of deamino-NADP and normal heat stability as well as normal pH curve.Keywords
This publication has 16 references indexed in Scilit:
- Two new glucose 6-phosphate dehydrogenase variants associated with congenital nonspherocytic hemolytic anemia found in Japan: Gd(-) tokushima and gd(-) tokyoAmerican Journal of Hematology, 1976
- Gd (−) Matam, an african glucose-6-phosphate dehydrogenase variant with enzyme deficiency. Biochemical and immunological properties in various hemopoietic tissuesClinica Chimica Acta; International Journal of Clinical Chemistry, 1975
- Gd(-) Abrami a deficient G-6PD variant with hemizygous expression in blood cells of a woman with primary myelofibrosisPublished by Springer Nature ,1975
- Human glucose-6-phosphate dehydrogenase variants: a supplementary tabulationAnnals of Human Genetics, 1973
- Glucose 6-phosphate dehydrogenase: Identity of erythrocyte and leukocyte enzyme with report of a new variant in ChineseBiochemical Genetics, 1972
- Congenital nonspherocytic hemolytic disease (CNHD) due to a G-6-PD variant: G-6-PD Kyoto.1972
- Human glucose-6-phosphate dehydrogenase variants.1971
- Variants of Glucose-6-phosphate Dehydrogenase in IndonesiaNature, 1969
- Evidence for four types of erythrocyte glucose-6-phosphate dehydrogenase from G-6-PD-deficient human subjects.Journal of Clinical Investigation, 1966
- Sex-linkage of the Glucose-6-phosphate Dehydrogenase Gene in EquidaeNature, 1966