Discovery of a Series of Cyclohexylethylamine-Containing Protein Farnesyltransferase Inhibitors Exhibiting Potent Cellular Activity
- 16 October 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 42 (23) , 4844-4852
- https://doi.org/10.1021/jm990335v
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein TransferaseJournal of Medicinal Chemistry, 1999
- Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cellsBioorganic & Medicinal Chemistry Letters, 1999
- Potent and Selective Non-Cysteine-Containing Inhibitors of Protein FarnesyltransferaseJournal of Medicinal Chemistry, 1998
- Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazineJournal of Medicinal Chemistry, 1998
- Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor CompoundsJournal of Medicinal Chemistry, 1997
- Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal CellsScience, 1993
- 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additiveJournal of the American Chemical Society, 1993
- PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONSAnnual Review of Genetics, 1992
- All ras proteins are polyisoprenylated but only some are palmitoylatedCell, 1989
- p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide FragmentsJournal of the American Chemical Society, 1973