Effects of FK506 on Exocrine Pancreas in Rats
- 1 March 1992
- journal article
- research article
- Published by Wolters Kluwer Health in Pancreas
- Vol. 7 (2) , 197-204
- https://doi.org/10.1097/00006676-199203000-00011
Abstract
The efficacy of FK506 on exocrine pancreas was studied in rats. Male Sprague-Dawley rats (230–250 g) received an i.m. daily injection of FK506 (0.1, 0.5, or 5.0 mg/kg), cyclosporine (CS; 25 mg/kg), or saline for 2 weeks. Isolated dispersed pancreatic acini were prepared from rats, and enzyme content of the cells and secretory response to cholecystokinin (CCK) were determined. Amylase and trypsin contents were increased in a dose-related manner by FK506 (pKeywords
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