Calcium, Cross-Bridges, and the Frank-Starling Relationship
- 1 February 2001
- journal article
- research article
- Published by American Physiological Society in Physiology
- Vol. 16 (1) , 5-10
- https://doi.org/10.1152/physiologyonline.2001.16.1.5
Abstract
The steep relationship between active force and length in cardiac muscle is based on a length dependence of myofilament Ca2+ sensitivity. However, it is not muscle length but the lateral spacing between actin and myosin filaments that sets the level of Ca2+ sensitivity, mainly through modulation of myosin-mediated activation of the thin filament.Keywords
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