CHEMICAL AND BIOLOGICAL PROPERTIES OF THE HEMAGGLUTINATION ANTIGEN, A LIPOPOLYSACCHARIDE, OF MYCOBACTERIUM TUBERCULOSIS, VAR. HOMINIS

Abstract
As to the chemical nature of the antigen of the Middlebrook-Dubos hemagglutination reaction (Middlebrook and Dubos, 1948), it was preliminarily reported by the authors that the antigen was a macrbmolecular polysaccharide which had never been reported either chemically or biologically (Tsumita, Matsumoto and Mizuno, 1959) . To elucidate the high adsorbability onto red blood cells and specificity against antituberculous sera which are essential features of the antigen, this paper covers details of the fact that the antigen could be obtained in a homogeneous state under ultracentrifugal forces and it contained lipid as a constituent, that is to say, it was a new lipopolysaccharide. The chemical and biological properties including stability of the antigen and specificity of the hemagglutination reaction are also reported in this paper.

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