Estrogenic Effect of Genistein and Coumestrol Diacetate

Abstract
Two nonsteroid compounds, coumestrol diacetate and genistein, were shown to stimulate the incorporation of labeled precursors into protein, phospholipid and ribonucleic acid and to increase acid soluble uridine triphosphate in the uterus of the ovariectomized rat. A comparison of their activity is made with that of estradiol and the possibility that the nonsteroid compounds may function in the same manner as the steroid estrogen is discussed.