Effect of Sodium Deficiency on Cochlear Potentials

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Abstract
The scala tympani in guinea pigs was prefused with mammalian Ringer-Locke''s solution, in which NaCl was replaced with either choline or sucrose. Cochlear potentials were recorded from the basal turn before, during, and subsequent to the perfusion. Complete replacement of the perilymph with Na+-free solution did not alter the endocochlear potential and the cochlear microphonic immediately, although the action potential was abolished rapidly. In most cases, the depression of the action potential was reversible. The mechanism underlying the generation of the receptor potential is discussed, and production of cochlear microphonic is not dependent on the concentration of Na+ in the peri-lymph but on the presence of high K+ concentration in the endolymph.

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