A Type 3 Attenuated Poliovirus Genetically Stable after Human Intestinal Passage.
- 1 August 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 107 (4) , 829-834
- https://doi.org/10.3181/00379727-107-26769
Abstract
Development of a new type 3 attenuated poliovirus (WM-III) is described. Starting with the W-Fox strain, passage and clone selection at 23°C were employed to develop a strain with improved stability after human intestinal passage. The end result was a virus which had no capacity to grow at 40°C and was not virulent for monkeys injected intracerebrally. The results of tests of fecal virus strains isolated from infants fed the WM-III strain did not show the instability in relation to laboratory markers that has been reported with other attenuated type 3 viruses.Keywords
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