TRYPANOCIDAL EFFECT OF DIAMIDINE 98-202 IN EXPERIMENTAL TRYPANOSOMA-RHODESIENSE INFECTION OF STUMPTAILED MACAQUE (MACACA-ARCTOIDES)

  • 1 January 1976
    • journal article
    • research article
    • Vol. 27  (2) , 238-244
Abstract
The trypanocidal effect of preparation 98/202 a 6-amidino-2-(4''-amidinophenyl)-thionaphthene dilactate, was investigated in 4 stumptailed macaques (M. arctoides) infected with T. rhodesiense (strain: Hamburg, 1962), of which 2 animals were treated previously with diminazene and pentamidine, respectively. The curative treatment with preparation 98/202 was carried out in all cases in the late stage of infection; at the beginning of treatment 3 of the 4 animals had already shown malaise with distinct affection of the central nervous system. The individual dose was 5 mg/kg (base) and was given by deep i.m. injection on 2, 3 or 4 consecutive days. During the trial period elimination of the parasites from the blood was observed in all monkeys, and in 3 of 4 animals also in the CSF. In 1 animal a parasitological cure could be demonstrated. Two animals died as a result of the very advanced infection; 1 animal had to be killed prematurely because of numerous deep skin necroses without healing tendency. In 2 animals previously treated with diminazene and pentamidine, respectively, the T. rhodesiense strain developed a distinct resistance to pentamidine, diminazene and preparation 98/202. The resistance induced with pentamidine against diminazene and preparation 98/202 was only transitory and disappeared after withdrawal of the preparation. A brief description of the course of infection is given and possible sites of action of preparation 98/202 are discussed.

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