Faculty Opinions recommendation of Nephrotoxic effects in high-risk patients undergoing angiography.

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Abstract
Current data indeed contradict the promising results reported by Aspelin et al. Bettmann evaluated recent published studies and reports that the incidence of contrast nephropathy is comparable, whether a low-osmolar agent or iso-osmolar agent is used {1}. When looking at the central role hypoxia plays in the pathogenesis of contrast nephropathy, this is not surprising. Liss et al. report that iso-osmolar agents reduce renal medullary oxygenation to the same extent as low-osmolar agents {2}. {1} Bettman, Nephrol Dial Transpl 2005, 20: i12-i17; {2} Liss et al., Kidney Int 1998, 53:698-702 [PMID:9507216].

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