Use of Mathematical Models in the Study of Structure-Toxicity Relationships of Dental Compounds: I. Esters of Acrylic and Methacrylic Acids
- 1 March 1972
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 51 (2) , 526-535
- https://doi.org/10.1177/00220345720510024701
Abstract
The toxicity of a series of esters of acrylic and methacrylic acids was determined in groups of mice, and the resultant LD50 values were analyzed with the use of the mathematical models of Free and Wilson and of Hansch to relate structure of the compounds to toxicity. Both models proved valuable in relating structures to toxicity parameters, but the more useful method for predicting toxicity was the Hansch model.Keywords
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