Further Studies on the Monkey Anti-Anemia Factor Deficiency Produced by Riboflavin Deficiency

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Abstract
Young rhesus monkeys fed a purified diet deficient in riboflavin developed a condition which did not respond completely to riboflavin therapy. The initial improvement was followed by a period of suboptimum growth and blood picture. This syndrome, characteristic of a lack of the MAAF, was alleviated by PGA at a level 10 times the minimum daily requirement of the normal monkey. A methanol extract of liver of very low PGA content was likewise effective. It is suggested that the efficacy of the liver extract was due to its content of the MAAF, and that of the PGA is attributed to its favorable influence on the intestinal flora which produce this factor.