IMMUNOLOGICAL EFFECTS OF EXPERIMENTAL IODINE TOXICOSIS IN YOUNG CATTLE

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (4) , 539-543
Abstract
Iodine compounds are commonly used as feed additives to treat or to prevent cattle diseases such as infectious pododermatitis, bovine respiratory disease complex, mastitis, infertility and actinomycotic infections. A study was designed to evaluate effects of 4 dosage levels (0, 50, 250 or 1250 mg) of daily I supplementation on cell-mediated and humoral immune mechanisms in 40 calves, 10 per group, for 6 mo. Immune and inflammatory responses were measured by titers to brucella, leptospira and infectious bovine rhinotracheitis virus vaccinations, by stimulation of lymphocyte mitoses with pokeweed, phytohemagglutinin (PHA), and concanavalin A mitogens, by intradermal PHA responses, by in vitro phagocytosis of Candida albicans by WBC [white blood cells], and by total WBC counts. Calves given 1250 mg of I daily had significant (P = < 0.05) decreases in persistence of antibody titers to brucella and leptospira organisms, in lymphocyte mitotic activity, in PHA injection induration, in phagocytosis by WBC, and in WBC counts. Calves fed I at 50 or 250 mg daily tended to have decreased leptospiral titers, lymphocyte mitoses, PHA injection induration, and in vitro phagocytosis by WBC compared with responses of controls. Large amounts of dietary I interfere with titer maintenance to some antigens, with lymphocyte DNA synthesis and with phagocytic activity of WBC.

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