Heterocyclic variants of the 1,5‐benzodiazepine system. V. Derivatives of 2‐(ortho‐R1‐anilino)‐4‐(p‐R2‐phenyl)‐3H‐1,5‐benzodiazepines
- 1 January 1989
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 26 (1) , 119-124
- https://doi.org/10.1002/jhet.5570260121
Abstract
Mono‐N‐methylation of 2‐(ortho‐R1‐anilino)‐4‐(p‐R2‐phenyl)‐3H‐1,5‐benzodiazepines IV is achieved in moderate yield with sodium hydride in methyl iodide. Reaction of the N‐methyl derivatives I with methoxyacetyl chloride gave the compounds II and III. The structure of all products was confirmed by ir, 1H‐nmr and mass spectrometry.Keywords
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