COMPARATIVE, DOUBLE-BLIND-STUDY ON TOLFENAMIC ACID IN THE TREATMENT OF RHEUMATOID-ARTHRITIS

  • 1 January 1979
    • journal article
    • research article
    • No. 24,p. 13-16
Abstract
Patients [60] with diagnosed rheumatoid arthritis were treated at random with tolfenamic acid, a new nonsteroid anti-inflammatory analgesic, in a daily dose of 600 mg, or with phenylbutazone 300 mg or acetylsalicylic acid 1500 mg daily. Both the patients and the physician found that tolfenamic acid had a clearly better effect than phenylbutazone or the low-dose acetylsalicylic acid used as a control. Tolfenamic acid and acetylsalicylic acid were well tolerated. Serious side-effects (leukopenia and thrombocytopenia in 1 case, hematemesis and melena in another) only occurred in those patients who received phenylbutazone.

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