Studies of stereochemical influences upon anti-histaminic activity. The synthesis, configuration, and anti-histaminic properties of some isomeric aminobutenes
- 1 February 1969
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 47 (3) , 423-427
- https://doi.org/10.1139/v69-061
Abstract
The acid-catalyzed dehydration of 4-dimethylamino-2-p-methoxyphenyl-1-phenylbutan-2-ol yields all four possible 4-amino-1,2-diarylbutenes. Pure samples of each isomer have been isolated, double bond positions and configurations being established from proton magnetic resonance and ultraviolet spectroscopic data. A stereoselective route to cis aminobut-1-enes has been further investigated. The anti-histaminic properties of the reported butenes together with some related compounds are given and structural influences upon activity discussed.Keywords
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