Nephrotoxic Serum Nephritis in Mice with a Genetic Deficiency in Complement

Abstract
Summary: Complement-containing progeny from the hybridization of B10.D2-old line females with B10.D2-new line males were used to study the role of the complement system in immune tissue injury. Small differences in the severity of nephrotoxic serum nephritis were found following the injection of nephrotoxic serum which implicate the late acting complement components as intensifiers of tissue injury.