A CLINICAL EVALUATION OF SOME NEW CURARE PREPARATIONS

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Abstract
D-Tubocurarine chloride, the dimethyl ether of d-tubocurarine iodide, and the dimethyl ether of d-tubocurarine chloride were quantitatively evaluated with regard to relaxation and respiratory paralysis. Each drug was used with both N2O and cyclopropane anesthesia. From the data obtained, the age, effective dose, relaxation, and respiratory paralysis were analyzed by the method of multiple covariance. A standard relaxation factor was established by the statistical analysis. More d-tubo- curarine chloride was required for a certain effect than the methylated chloride or iodide compounds. Comparisons of respiratory paralysis failed to show a difference between d-tubocurarine chloride, and the mean of the 2 methylated compounds during N2O anesthesia. The comparisons during cyclopropane anesthesia were essentially the same except that the difference in methylated compounds was significant. The methylated compounds were more potent than d-tubocurarine chloride. For equivalent relaxation the degree of respiratory paralysis produced by d-tubocurarine chloride was the same as that produced by the methylated compounds.
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