Laboratory Data Analysis System: Section V—Trend Analysis

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Abstract
Grams, Ralph R., Johnson, Eugene A., and Benson, Ellis S.: Laboratory data analysis system. Section V: Trend analysis. Am. J. Clin. Pathol. 58: 208–215, 1972. Trend analysis is presented as the fourth analytic part of a Laboratory Data Analysis System. This package analyzes laboratory results with respect to time and uses a catalog of experimentally defined information for reference. The example presented in this paper is a study of myocardial infarction by means of serum enzymes (total lactate dehydrogenase, heat stable lactate dehydrogenase, serum glutamic oxalacetic transaminase, ornithine carbonyl transaminase and creatinine phosphokinase). A specific mathematical model which fits well with the observed and theoretical description of this disease was developed from a prospective patient study. Such a model could be routinely used for diagnosis, prognosis, and therapy. It is evident that time is an important variable in the study of disease, and only through collecting sequential readings will trends be evident and expressed for clinical evaluation. This example of trend research lends strong support to the value and potential developments which could result from a Medical Information System in which all patient data were stored and retrievable.

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