Inhibition of the bacteriolytic effect of β‐lactam‐antibiotics onStaphylococcus aureusby the polyanionic drugs suramin and Evans Blue*

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Abstract
The anionic polyelectrolytes suramin and Evans Blue inhibited different autolytic systems involved in wall growth and wall turnover of growing staphylococci and in wall autolysis of resting bacteria. Moreover, both substances lowered the β‐lactam‐induced pre‐lytic release of cytoplasmic constituents from staphylococci, and inhibited the β‐lactam‐induced bacteriolysis as well as the loss of viability. The protective effects of these sulfonated drugs against bacteriolysis were also monitored by electron microscopy. Some medical implications of our results are discussed.

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