Canine Endotoxin Shock: Reversal with Aldosterone and Angiotensin II (Hypertensin)

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Abstract
Aldosterone, alone, was first shown to protect animals against endotoxin when Halberg, Spink and Bittner(4) used preparations of the steroid in adrenalectomized mice. Bein and Jaques (5) corroborated and extended these observations with more satisfactory preparations of aldosterone in mice, rats and cats. Studies in our laboratory indicate that aldosterone is the most potent corticosteroid available for potentiating the pressor effect of pressor agents in experimental endotoxin shock. The results with the aldosterone-angiotensin II combination are especially impressive.

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