STUDIES ON DEVELOPMENT OF SERUM-LIPOPROTEINS FROM FETAL TO ADULT AGE OF RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 37  (2) , 239-244
Abstract
The semi-quantitative development of lipoproteins in the serum (.beta.-, pre-.beta.- and .alpha.-lipoproteins) from fetal (day 18 of intra-uterine development) to adult age was determined by agarose gel electrophoresis and determination of total lipids. A high proportion of .beta.- and a very low proportion of pre-.beta.-lipoprotein is typical of the fetal stage. In adults, however, the .beta.-lipoproteins are the smallest fraction, and the pre-.beta.-lipoproteins the 2nd-largest fraction. The transition from fetal to adult lipoprotein pattern is more or less abrupt, with the change of the proportion for each of the 3 lipoprotein fractions occurring at different intervals from birth. Adaptation of the fetal lipoprotein status to that of the adult animal in regard to quantity and mutual relationship of the fractions was observable, at the earliest, 7 wk after birth.

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