Considerations on the Significance Attributed to Unusual Cerebral Histological Findings Recently Described in Eight Patients with Primary Generalized Epilepsy

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Abstract
The pathological nature of the histological features reported by Meencke and Janz in the brains of 8 patients suffering from primary generalized epilepsy was investigated. Most of the histological findings considered abnormal are commonly seen in neurologically normal controls. True minor dysgenetic changes were observed in individuals free of cerebral disorders. The hypothesis drawn from the neuropathological observations to explain the etiopathogenesis of this category of epilepsy and the physiopathogenesis of the seizures does not seem acceptable.