PDZ interactions and proximal tubular phosphate reabsorption
- 1 November 2004
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Renal Physiology
- Vol. 287 (5) , F871-F875
- https://doi.org/10.1152/ajprenal.00244.2004
Abstract
In adults, the extent of renal reabsorption of Pi and consequently the extent of urinary excretion of phosphate are to a large extent determined by the abundance of the Na-Pi cotransporter NaPi-IIa (SLC34A1). Localization of this cotransporter is restricted to the apical membrane of proximal tubular cells, and its abundance is controlled by a number of factors and pathophysiological conditions. To guarantee a proper apical localization and specific regulated endocytosis of NaPi-IIa, an orchestrated pattern of protein interactions has to be envisaged. Attempts to screen for such interacting proteins resulted in the identification of a PDZ domain containing proteins. The purpose of this review is to discuss the roles of these PDZ proteins in proximal tubular Na-Pi cotransport.Keywords
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