Lysis, induced by cefoxitin sodium, of Gram-negative bacteria containing various R-factors

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Abstract
Cefoxitin sodium, a semi-synthetic member of the cephamycin group of β-lactam antibiotics, was inhibitory at low concentration to β-lactamase-producing (including R + ) and non-β-lactamase-producing strains of Gram-negative bacteria. It was resistant to destruction by crude β-lactamase preparations. Its lytic effect on actively growing cells (in broth) of Escherichia coli strains with and without various R-factors (RP1, R1, TEM and RGN 238) was studied. At concentrations at or near its minimum inhibitory concentration, cefoxitin was rapidly bacteriolytic to all these strains. Cefoxitin induced spheroplast formation of Proteus spp. in nutrient broth with or without added sucrose and magnesium ions.

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