STUDIES ON THE MECHANISM OF NIDATION. XXVIII.

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Abstract
The origin of the uterine eosinophilic granulocytes in the rat has been investigated. Following ovariectomy the uteri of cyclic rats become depleted of eosinophilic granulocytes within two weeks. Administration of oestrogen to female rats three weeks after ovariectomy was followed by marked uterine eosinophilia within 48 hours. When ovariectomized rats were given tritiated thymidine (precursor for DNA) for a period of six days, autoradiographs of smears of bone marrow and peripheral blood showed that the nucleated elements were labelled, but at the same time tritiated thymidine was not incorporated in the uterus, except in some epithelial cells of lumen and glands. Following administration of oestrogen after cessation of the treatment with tritiated thymidine, eosinophilia was induced in the uteri of the ovariectomized rats. All the infiltrating eosinophilic granulocytes were labelled, indicating that these cells had originated from the bone marrow and had infiltrated the uterus under the influence of oestrogen. The conclusion is reached that the eosinophilic granulocytes which appear periodically in the uterus of the rat in certain physiological states (e. g. oestrus of the normal cycle) originate from haematopoetic sites in the bone marrow, and are not produced locally from cells within the uterus itself.

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