Unsustained Ventricular Tachycardia — To Treat or Not to Treat

Abstract
Physicians have long struggled with the vexing problem of how best to treat patients with myocardial infarction, reduced left ventricular function, and asymptomatic unsustained ventricular tachycardia who may be at risk for sudden death due to ventricular fibrillation. The Multicenter Automatic Defibrillator Implantation Trial (MADIT) was a randomized clinical trial that addressed whether such patients might benefit from an implantable cardioverter–defibrillator. In this trial patients with asymptomatic unsustained ventricular tachycardia who had inducible sustained ventricular tachycardia or ventricular fibrillation that remained inducible after the intravenous administration of procainamide were randomly assigned to receive implantable cardioverter–defibrillators or antiarrhythmic-drug therapy. The results . . .

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