Gastric Acid Secretion in Different Strains of Rats during Pyloric Ligation and Cholinergic Stimulation

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Abstract
Gastric acid secretion was studied in four strains of rats paired by age during a 3-hour pyloric ligation. The secretion decreased from Sherman to Sprague-Dawley, Long-Evans and Wistar. The fact that the difference persists during a maximal cholinergic stimulation supports the hypothesis that it might be related to a variation in parietal cell mass or to a difference of vagal tone. A direct comparison of three groups of Sherman and Wistar, paired by weight from 130 to 200 g, rules out the possibility that this variation among strains is due to difference in weight. Therefore, the strain is a determinant factor for gastric response to carbaminoylcholine.

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