PHARMACOKINETICS OF CEFAMANDOLE IN PATIENTS UNDERGOING HEMODIALYSIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 17  (9) , 416-420
Abstract
The pharmacokinetics of cefamandole was studied in 17 patients with terminal renal impairment, 10 of which were undergoing hemodialysis sessions while 7 were in the period between dialysis sessions. An open 2-compartment kinetic model was used to described the biphasic decrease of the plasma concentrations of cefamandole, thus establishing the amounts of the antibiotic in the peripheral and central compartments together with the amount eliminated. All patients received an i.v. bolus injections of 15 mg/kg body wt. During the hemodialysis sessions, the pharmacokinetic parameters of cefamandole were calculated. There is a decrease in the overall elimination constant compared with that obtained during the periods between the dialysis sessions. A dosage regimen of multiple dose is established as a function of the pharmacokinetic parameters of the antibiotic for patients with terminal renal impairment undergoing periodic sessions of hemodialysis.

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